Hyperoxaluria

Hyperoxaluria type I is an autosomal recessive disease, caused by the deficiency of the enzyme alanine-glyxylate aminotransferase, localized in the peroxisomes of the hepatocyte &, and characterized by oxalate overproduction, resulting in oxalate deposition in the kidney, heart, and bone &.
Liver transplantation or combined liver and kidney transplantation, when kidney failure develops, is the curative treatment of the disease.